| <P><FONT size=1><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">《中华神经科杂志》一篇研究表明：脑梗死二级预防中阿司匹林抵抗</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>(AR)</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">发生率高，</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>AR</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">与脑梗死复发及其他血管事件的发生密切相关。</SPAN></FONT></P>
<P><FONT size=1><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial"></SPAN></FONT><FONT size=1><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">研究者选取</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>600</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">例脑梗死患者，入院当天开始服用阿司匹林，服用</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>7</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">～</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>10 d</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">后检测血小板聚集率，筛选出</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>AR</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">患者及敏感患者，并对患者进行</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>6</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">～</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>24</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">个月随访，观察脑梗死复发及其他血管事件发生情况，分析</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>AR</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">及血管事件发生的危险因素和预后。</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US><?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></FONT></P>
<P><FONT size=1><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">结果出现</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>AR</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">者</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>150</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">例</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>(25.0%)</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">，敏感者</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>450</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">例</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>(75.0%)</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">；</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>AR</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">组女性、糖尿病患者比例及血低密度脂蛋白</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>(LDL)</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">胆固醇水平均高于阿司匹林敏感组；糖尿病</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>(OR=2.58)</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">、高</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>LDL</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">血症</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>(OR=1.89)</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">为</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>AR</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">发生的独立危险因素。</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US><o:p></o:p></SPAN></FONT></P>
<P><FONT size=1><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>AR</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">组随访期脑梗死复发率、心肌梗死发生率以及全因死亡率均高于阿司匹林敏感组；糖尿病</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>(OR=2.47)</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">、动脉粥样硬化血栓型脑梗死</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>(OR=2.13)</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">及</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>AR(OR=3.86)</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">是随访期血管事件发生的独立危险因素，有</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>AR</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">者血管事件发生的风险增加</SPAN><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US>3.86</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial">倍。</SPAN></FONT><SPAN style="FONT-FAMILY: Arial; COLOR: black" lang=EN-US><o:p></o:p></SPAN></P> |
