| <P><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">一项小型研究显示，纳曲酮（</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">Naltrexone</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">，一种用于治疗酒精依赖的治疗药物），可能只对那些具有特定遗传基因的女性有效。</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></P>
<P><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">纳曲酮主要通过降低酒精诱导的过度兴奋而治疗酒精成瘾，目前是治疗该疾病的最佳方案。</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P>
<P><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">加拿大一个研究小组比较了纳曲酮</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">6</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">天疗程同安慰剂的治疗效果，共纳入</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">40</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">例饮酒者，一半是女性。在每个疗程结束时，受试者会接受饮酒测试。</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P>
<P><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">研究报告说，纳曲酮只对女性以及具有鸦片受体基因（</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">OPRM1</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">）中的</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial">A118G</SPAN><SPAN style="COLOR: black; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">基因的参与者才具有减少酒精诱导的过度兴奋作用。该研究有助于发现那些最可能从纳曲酮治疗中获益的患者。不过，未来还需要更多的样本去研究大脑的类鸦片活性肽系统、基因以及纳曲酮不同应答之间的联系。</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P>
<P><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Arial"><o:p> </o:p></SPAN></P> |
