| <P><FONT color=#2e3d47><SPAN style="FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-weight: bold">瑞巴派特（</SPAN><SPAN lang=EN-US style="mso-bidi-font-weight: bold"><FONT face=Arial>rebamipid</FONT></SPAN><SPAN style="FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-weight: bold">，</SPAN><SPAN lang=EN-US style="mso-bidi-font-weight: bold"><FONT face=Arial>Mucosta</FONT></SPAN><SPAN style="FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-weight: bold">）原为</SPAN><SPAN lang=EN-US style="mso-bidi-font-weight: bold"><FONT face=Arial>Otsuka</FONT></SPAN><SPAN style="FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-weight: bold">制药公司的抗胃溃疡药，而该公司最近在日本首次申报其眼用混悬液产品用于新适应症——干眼症，此前在日本进行的临床试验阳性结果表明，该产品能改善干眼症所致角膜</SPAN><SPAN lang=EN-US style="mso-bidi-font-weight: bold"><FONT face=Arial>-</FONT></SPAN><SPAN style="FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial; mso-bidi-font-weight: bold">结膜损伤和自觉症状（包括眼部疼痛、眼中有沙子感觉和视力模糊）。干眼症为一种常见慢性疾病，由于缺少自燃眼泪和眼黏膜液，可导致角膜和结膜上皮损伤。</SPAN><SPAN lang=EN-US style="mso-bidi-font-weight: bold"><?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></FONT></P>
<P><FONT color=#2e3d47><SPAN style="FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">瑞巴派特为一种黏膜保护剂，</SPAN><SPAN lang=EN-US><FONT face=Arial>1999</FONT></SPAN><SPAN style="FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">年作为口服抗胃溃疡药首次在日本上市，随后又获准用于治疗胃炎引起的胃黏膜损伤。它可促进环氧合酶</SPAN><SPAN lang=EN-US><FONT face=Arial>-2</FONT></SPAN><SPAN style="FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">（</SPAN><SPAN lang=EN-US><FONT face=Arial>COX-2</FONT></SPAN><SPAN style="FONT-FAMILY: 宋体; mso-ascii-font-family: Arial; mso-hansi-font-family: Arial">）的产生而诱导前列腺素的生成，也为活性氧自由基清除剂。其用于干眼症，能促进角膜和结膜产生黏蛋白，从而致使眼内形成一稳定水性层。该产品用于此适应症的Ⅱ期临床试验也正在美国进行。</SPAN></FONT><B><SPAN lang=EN-US><o:p></o:p></SPAN></B></P> |
